| First Author | Casson CN | Year | 2017 |
| Journal | PLoS Pathog | Volume | 13 |
| Issue | 4 | Pages | e1006309 |
| PubMed ID | 28384349 | Mgi Jnum | J:269879 |
| Mgi Id | MGI:5916610 | Doi | 10.1371/journal.ppat.1006309 |
| Citation | Casson CN, et al. (2017) Neutrophils and Ly6Chi monocytes collaborate in generating an optimal cytokine response that protects against pulmonary Legionella pneumophila infection. PLoS Pathog 13(4):e1006309 |
| abstractText | Early responses mounted by both tissue-resident and recruited innate immune cells are essential for host defense against bacterial pathogens. In particular, both neutrophils and Ly6Chi monocytes are rapidly recruited to sites of infection. While neutrophils and monocytes produce bactericidal molecules, such as reactive nitrogen and oxygen species, both cell types are also capable of synthesizing overlapping sets of cytokines important for host defense. Whether neutrophils and monocytes perform redundant or non-redundant functions in the generation of anti-microbial cytokine responses remains elusive. Here, we sought to define the contributions of neutrophils and Ly6Chi monocytes to cytokine production and host defense during pulmonary infection with Legionella pneumophila, responsible for the severe pneumonia Legionnaires' disease. We found that both neutrophils and monocytes are critical for host defense against L. pneumophila. Both monocytes and neutrophils contribute to maximal IL-12 and IFNgamma responses, and monocytes are also required for TNF production. Moreover, natural killer (NK) cells, NKT cells, and gammadelta T cells are sources of IFNgamma, and monocytes direct IFNgamma production by these cell types. Thus, neutrophils and monocytes cooperate in eliciting an optimal cytokine response that promotes effective control of bacterial infection. |
