| First Author | Kadoki M | Year | 2017 |
| Journal | Cell | Volume | 171 |
| Issue | 2 | Pages | 398-413.e21 |
| PubMed ID | 28942919 | Mgi Jnum | J:252193 |
| Mgi Id | MGI:5926898 | Doi | 10.1016/j.cell.2017.08.024 |
| Citation | Kadoki M, et al. (2017) Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues. Cell 171(2):398-413.e21 |
| abstractText | A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic map of immune processes at the organism level. We uncover two inter-organ mechanisms of protective immunity mediated by soluble and cellular factors. First, analyzing ligand-receptor connectivity across tissues reveals that type I IFNs trigger a whole-body antiviral state, protecting the host within hours after skin vaccination. Second, combining parabiosis, single-cell analyses, and gene knockouts, we uncover a multi-organ web of tissue-resident memory T cells that functionally adapt to their environment to stop viral spread across the organism. These results have implications for manipulating tissue-resident memory T cells through vaccination and open up new lines of inquiry for the analysis of immune responses at the organism level. |
