| First Author | Dalton DK | Year | 1993 |
| Journal | Science | Volume | 259 |
| Issue | 5102 | Pages | 1739-42 |
| PubMed ID | 8456300 | Mgi Jnum | J:66802 |
| Mgi Id | MGI:1929257 | Doi | 10.1126/science.8456300 |
| Citation | Dalton DK, et al. (1993) Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments]. Science 259(5102):1739-42 |
| abstractText | Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system. |
