| First Author | Zhou J | Year | 2023 |
| Journal | Front Immunol | Volume | 14 |
| Pages | 1322536 | PubMed ID | 38164135 |
| Mgi Jnum | J:344277 | Mgi Id | MGI:7571760 |
| Doi | 10.3389/fimmu.2023.1322536 | Citation | Zhou J, et al. (2023) Vaccine induced memory CD8(+) T cells efficiently prevent viral transmission from the respiratory tract. Front Immunol 14:1322536 |
| abstractText | INTRODUCTION: Mucosal immunization eliciting local T-cell memory has been suggested for improved protection against respiratory infections caused by viral variants evading pre-existing antibodies. However, it remains unclear whether T-cell targeted vaccines suffice for prevention of viral transmission and to which extent local immunity is important in this context. METHODS: To study the impact of T-cell vaccination on the course of viral respiratory infection and in particular the capacity to inhibit viral transmission, we used a mouse model involving natural murine parainfluenza infection with a luciferase encoding virus and an adenovirus based nucleoprotein targeting vaccine. RESULTS AND DISCUSSION: Prior intranasal immunization inducing strong mucosal CD8+ T cell immunity provided an almost immediate shut-down of the incipient infection and completely inhibited contact based viral spreading. If this first line of defense did not operate, as in parentally immunized mice, recirculating T cells participated in accelerated viral control that reduced the intensity of inter-individual transmission. These observations underscore the importance of pursuing the development of mucosal T-cell inducing vaccines for optimal protection of the individual and inhibition of inter-individual transmission (herd immunity), while at the same time explain why induction of a strong systemic T-cell response may still impact viral transmission. |
