| First Author | Greer RL | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 13329 | PubMed ID | 27841267 |
| Mgi Jnum | J:242714 | Mgi Id | MGI:5906090 |
| Doi | 10.1038/ncomms13329 | Citation | Greer RL, et al. (2016) Akkermansia muciniphila mediates negative effects of IFNgamma on glucose metabolism. Nat Commun 7:13329 |
| abstractText | Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNgamma on glucose tolerance. In IFNgamma-deficient mice, A. muciniphila is significantly increased and restoration of IFNgamma levels reduces A. muciniphila abundance. We further show that IFNgamma-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFNgamma-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFNgamma-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFNgamma, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans. |
