| First Author | Sun J | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 4 | Pages | 327-34 |
| PubMed ID | 21297642 | Mgi Jnum | J:170347 |
| Mgi Id | MGI:4946346 | Doi | 10.1038/ni.1996 |
| Citation | Sun J, et al. (2011) CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 12(4):327-34 |
| abstractText | Interleukin (IL)-10 is an important regulatory cytokine that can modulate excessive immune mediated injury. Several distinct cell types have been demonstrated to produce IL-10, including most recently CD8(+) cytotoxic T lymphocytes (CTLs) responding to respiratory virus infection. Here we report that CD4(+) T cell help in the form of IL-2 is required for IL-10 production by CTLs, but not for the induction of CTL effector cytokines. We show that IL-2 derived from CD4(+) helper T cells cooperates with innate immune cell-derived IL-27 to amplify IL-10 production by CTLs through a Blimp-1-dependent mechanism. These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection. |
