| First Author | Dandekar AA | Year | 2004 |
| Journal | Am J Pathol | Volume | 164 |
| Issue | 2 | Pages | 363-9 |
| PubMed ID | 14742242 | Mgi Jnum | J:88552 |
| Mgi Id | MGI:3034112 | Doi | 10.1016/S0002-9440(10)63126-4 |
| Citation | Dandekar AA, et al. (2004) Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am J Pathol 164(2):363-9 |
| abstractText | Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a disease that shares many histological characteristics with multiple sclerosis. We previously demonstrated that JHM-infected mice that only have CD8 T cells specific for an epitope not in the virus develop demyelination on specific activation of these cells. Herein we show that this process of bystander T-cell-mediated demyelination is interferon-gamma (IFN-gamma)-dependent. The absence of IFN-gamma abrogated demyelination but did not change T-cell infiltration or expression levels of inflammatory cytokines or chemokines in the spinal cord. These results are consistent with models in which IFN-gamma contributes to CD8 T-cell-mediated demyelination by activation of macrophages/microglia, the final effector cells in the disease process. |
