| First Author | Oldenhove G | Year | 2018 |
| Journal | Cell Rep | Volume | 25 |
| Issue | 8 | Pages | 2053-2060.e4 |
| PubMed ID | 30463004 | Mgi Jnum | J:270400 |
| Mgi Id | MGI:6278496 | Doi | 10.1016/j.celrep.2018.10.091 |
| Citation | Oldenhove G, et al. (2018) PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity. Cell Rep 25(8):2053-2060.e4 |
| abstractText | Recent observations clearly highlight the critical role of type 2 innate lymphoid cells in maintaining the homeostasis of adipose tissues in humans and mice. This cell population promotes beiging and limits adiposity directly and indirectly by sustaining a Th2-prone environment enriched in eosinophils and alternatively activated macrophages. Accordingly, the number and function of type 2 innate lymphoid cells (ILC2s) are strongly impaired in obese individuals. In this work, we identify the PD-1-PD-L1 pathway as a factor leading to ILC2 destabilization upon high-fat feeding resulting in impaired tissue metabolism. Tumor necrosis factor (TNF) appears to play a central role, triggering interleukin-33 (IL-33)-dependent PD-1 expression on ILC2s and recruiting and activating PD-L1(hi) M1 macrophages. PD-1 blockade partially restores the type 2 innate axis, raising the possibility of restoring tissue homeostasis. |
