| First Author | Lord GM | Year | 2005 |
| Journal | Blood | Volume | 106 |
| Issue | 10 | Pages | 3432-9 |
| PubMed ID | 16014561 | Mgi Jnum | J:123942 |
| Mgi Id | MGI:3719987 | Doi | 10.1182/blood-2005-04-1393 |
| Citation | Lord GM, et al. (2005) T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 106(10):3432-9 |
| abstractText | Inflammatory responses are controlled by T helper 1 (Th1) lymphocytes. An important function of this polarity is the ability of T cells to traffick appropriately in vivo. This differential trafficking is dependent upon the binding of P-selectin glycoprotein ligand-1 to P- and E-selectin on inflamed endothelium as well as the expression of specific chemokine receptors. Here we show that in the absence of T-box expressed in T cells (T-bet), selective migration of T cells in vivo is completely abrogated and that T-bet regulates the binding of CD4(+) T cells to P-selectin. T-bet is also required for the expression of the chemokine receptor CXCR3. Thus, T-bet controls Th1-cell migration to inflammatory sites, which has fundamental consequences for the control of immunologic disease. |
