| First Author | Hirako IC | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 13277 | PubMed ID | 27808089 |
| Mgi Jnum | J:338002 | Mgi Id | MGI:6207190 |
| Doi | 10.1038/ncomms13277 | Citation | Hirako IC, et al. (2016) Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria. Nat Commun 7:13277 |
| abstractText | Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b(+)F4/80(+)CD11c(+)MHCII(high)DC-SIGN(high)Ly6c(+) and express high levels of CCR5, CXCL9 and CXCL10 (CCR5(+)CXCL9/10(+) MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5(+)CXCL9/10(+) MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8(+) T lymphocytes, leading to a lethal neuropathological syndrome. |
