| First Author | Blutt SE | Year | 2012 |
| Journal | Mucosal Immunol | Volume | 5 |
| Issue | 6 | Pages | 712-9 |
| PubMed ID | 22739233 | Mgi Jnum | J:308054 |
| Mgi Id | MGI:6719481 | Doi | 10.1038/mi.2012.51 |
| Citation | Blutt SE, et al. (2012) IgA is important for clearance and critical for protection from rotavirus infection. Mucosal Immunol 5(6):712-9 |
| abstractText | Based on a lack of severe phenotype in human immunoglobulin A (IgA) deficiency syndromes, the role of IgA in controlling respiratory and gastrointestinal (GI) infections has not been clearly defined. C57BL/6 and BALB/c mice lacking IgA (IgA(-/-)) were developed and used to address this question. When exposed to a common GI virus, rotavirus, IgA(-/-) mice exhibited a substantial and significant delay in clearance of the initial infection compared with wild-type mice. IgA(-/-) mice excreted rotavirus in stool up to 3 weeks after the initial exposure compared with 10 days observed in wild-type mice. Importantly, IgA(-/-) mice failed to develop protective immunity against multiple repeat exposures to the virus. All IgA(-/-) mice excreted virus in the stool upon re-exposure to rotavirus, whereas wild-type mice were completely protected against re-infection. These findings clearly indicate a critical role for IgA in the establishment of immunity against a GI viral pathogen. |
