| First Author | Hasan M | Year | 2002 |
| Journal | Eur J Immunol | Volume | 32 |
| Issue | 12 | Pages | 3463-71 |
| PubMed ID | 12442328 | Mgi Jnum | J:80853 |
| Mgi Id | MGI:2447284 | Doi | 10.1002/1521-4141(200212)32:12<3463::AID-IMMU3463>3.0.CO;2-B |
| Citation | Hasan M, et al. (2002) Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background. Eur J Immunol 32(12):3463-71 |
| abstractText | The expression of the preB cell receptor (preBCR), composed of the mu chain, surrogate light chains and the Igalpha /Igbeta signal transduction unit, permits further differentiation of Bcell precursors. C57BL/6 mice homozygous for an inactivating mutation of the membrane exon of the mu chain gene (C57BL/6muMT/muMT)) cannot form a preBCR and are, consequently, devoid of mature B lymphocytes. Here we present evidence that the block of B cell development by the muMT mutation is incomplete in BALB/c mice. Unlike C57BL/6muMT/muMT), BALB/cmuMT/muMT) mice generate small numbers of mature B cells, accumulate plasma cells and produce high levels of all immunoglobulin isotypes, except IgM. The observed phenomenon seems to be controlled by a single genetic locus that is not linked to IgH. |
