| First Author | Li C | Year | 2024 |
| Journal | J Exp Med | Volume | 221 |
| Issue | 3 | PubMed ID | 38353705 |
| Mgi Jnum | J:353288 | Mgi Id | MGI:7710837 |
| Doi | 10.1084/jem.20221042 | Citation | Li C, et al. (2024) Ion channel TRPV2 is critical in enhancing B cell activation and function. J Exp Med 221(3) |
| abstractText | The function of transient receptor potential vanilloid (TRPV) cation channels governing B cell activation remains to be explored. We present evidence that TRPV2 is highly expressed in B cells and plays a crucial role in the formation of the B cell immunological synapse and B cell activation. Physiologically, TRPV2 expression level is positively correlated to influenza-specific antibody production and is low in newborns and seniors. Pathologically, a positive correlation is established between TRPV2 expression and the clinical manifestations of systemic lupus erythematosus (SLE) in adult and child SLE patients. Correspondingly, mice with deficient TRPV2 in B cells display impaired antibody responses following immunization. Mechanistically, the pore and N-terminal domains of TRPV2 are crucial for gating cation permeation and executing mechanosensation in B cells upon antigen stimulation. These processes synergistically contribute to membrane potential depolarization and cytoskeleton remodeling within the B cell immunological synapse, fostering efficient B cell activation. Thus, TRPV2 is critical in augmenting B cell activation and function. |
