| First Author | León B | Year | 2012 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 7 | Pages | 681-90 |
| PubMed ID | 22634865 | Mgi Jnum | J:187654 |
| Mgi Id | MGI:5437592 | Doi | 10.1038/ni.2309 |
| Citation | Leon B, et al. (2012) Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells. Nat Immunol 13(7):681-90 |
| abstractText | Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7(+) naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4(+) T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. Notably, lymphotoxin-expressing B cells, CXCR5-expressing DCs and T cells, and CXCL13 were also necessary for development of interleukin 4 (IL-4)-producing type 2 helper T cells (T(H)2 cells), which suggests that T(H)2 differentiation can initiate outside the T cell zone. |
