| First Author | Tumanov A | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 3 | Pages | 239-50 |
| PubMed ID | 12354378 | Mgi Jnum | J:79129 |
| Mgi Id | MGI:2387258 | Doi | 10.1016/s1074-7613(02)00397-7 |
| Citation | Tumanov A, et al. (2002) Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 17(3):239-50 |
| abstractText | In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTbeta gene deleted from B cells (B-LTbeta KO mice). In contrast to systemic LTbeta deletion, in B-LTbeta KO mice only splenic microarchitecture was affected, while lymph nodes and Peyer's patches (PP) were normal, except for PP's reduced size. Even though B-LTbeta KO spleens retained a small number of follicular dendritic cells (FDC) which appeared to be dependent on LTbeta produced by T cells, IgG responses to sheep red blood cells were markedly reduced. Thus, the organogenic function of B-LTbeta is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response. |
