| First Author | ten Boekel E | Year | 1998 |
| Journal | Immunity | Volume | 8 |
| Issue | 2 | Pages | 199-207 |
| PubMed ID | 9492001 | Mgi Jnum | J:110438 |
| Mgi Id | MGI:3640232 | Doi | 10.1016/s1074-7613(00)80472-0 |
| Citation | ten Boekel E, et al. (1998) Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression. Immunity 8(2):199-207 |
| abstractText | Within the pools of muH chain-producing precursor and mature B cells from normal and lambda5-defective mice, the frequency of cells in which both H chain alleles were productively VHDJH rearranged was determined. An equally high percentage (2%-4%) of cells carrying two productively VHDJH-rearranged H chain loci was found in precursor and mature B cell pools of both mouse strains. In all of these cells, one allele encodes a muH chain incapable of forming a surface-expressed pre-B cell receptor. Hence, allelic exclusion is maintained at the level of pre-B cell receptor expression. The surprising conservation of H chain allelic exclusion in lambda5-defective B cells suggests that an alternative form of pre-B cell receptor might function to ensure this allelic exclusion. |
