| First Author | Gallagher E | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 1 | Pages | 57-63 |
| PubMed ID | 17143273 | Mgi Jnum | J:116622 |
| Mgi Id | MGI:3694589 | Doi | 10.1038/ni1421 |
| Citation | Gallagher E, et al. (2007) Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol 8(1):57-63 |
| abstractText | Mice lacking activity of the kinase MEKK1 ('Map3k1(DeltaKD)' mice) have defective activation of the kinase Jnk and increased production of T helper type 2 cytokines after T cell receptor ligation. Here we show that Map3k1(DeltaKD) mice had defective germinal center formation and diminished production of antibodies recognizing thymus-dependent antigens. Those defects were B cell intrinsic, as MEKK1 was necessary for CD40-mediated activation of the kinases Jnk and p38 and transcription factor c-Jun, as well as for expression of cyclin D2 and activation-induced deaminase. MEKK1 was recruited to CD40 and adaptor molecule TRAF2 after CD40 ligation, and Map3k1(DeltaKD) B cells were hypoproliferative after CD40 stimulation. Our data emphasize that MEKK1 is an essential component of signaling cascades needed for thymus-dependent antigen-induced B cell proliferation and antibody production. |
