| First Author | Guthmiller JJ | Year | 2017 |
| Journal | J Immunol | Volume | 198 |
| Issue | 2 | Pages | 617-622 |
| PubMed ID | 27940658 | Mgi Jnum | J:247660 |
| Mgi Id | MGI:5926617 | Doi | 10.4049/jimmunol.1601762 |
| Citation | Guthmiller JJ, et al. (2017) Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. J Immunol 198(2):617-622 |
| abstractText | IL-10 is a pleiotropic cytokine expressed during malaria, a disease characterized by short-lived, parasite-specific Ab responses. The role of IL-10 in regulating B cell responses during malaria is not known. In this study we report that IL-10 is essential for anti-Plasmodium humoral immunity. We identify that germinal center (GC) B cell reactions, isotype-switched Ab responses, parasite control, and host survival require B cell-intrinsic IL-10 signaling. IL-10 also indirectly supports humoral immunity by suppressing excessive IFN-gamma, which induces T-bet expression in B cells. Genetic ablation of either IFN-gamma signaling or T-bet expression in B cells substantially enhanced GC B cell responses and anti-Plasmodium Ab production. Together, our data show that B cell-intrinsic IL-10 enhances whereas B cell-intrinsic IFN-gamma and T-bet suppress GC B cell responses and anti-Plasmodium humoral immunity. These data identify critical immunoregulatory circuits in B cells that may be targeted to promote long-lived humoral immunity and resistance to malaria. |
