| First Author | Andreansky S | Year | 2004 |
| Journal | Proc Natl Acad Sci U S A | Volume | 101 |
| Issue | 7 | Pages | 2017-22 |
| PubMed ID | 14764895 | Mgi Jnum | J:88442 |
| Mgi Id | MGI:3033278 | Doi | 10.1073/pnas.0307320101 |
| Citation | Andreansky S, et al. (2004) The limits of protection by 'memory' T cells in Ig-/- mice persistently infected with a gamma-herpesvirus. Proc Natl Acad Sci U S A 101(7):2017-22 |
| abstractText | Can CD4(+) and CD8(+) 'memory' T cells that are generated and maintained in the context of low-level virus persistence protect, in the absence of antibody, against a repeat challenge with the same pathogen? Although immune T cells exert effective, long-term control of a persistent gamma-herpesvirus (gammaHV68) in Ig(-/-) microMT mice, subsequent exposure to a high dose of the same virus leads to further low-level replication in the lung. This lytic phase in the respiratory tract is dealt with effectively by the recall of memory T cells induced by a gammaHV68 recombinant (M3LacZ) that does not express the viral M3 chemokine binding protein. At least for the CD8(+) response, greater numbers of memory T cells confer enhanced protection in the M3LacZ-immune mice. However, neither WT gammaHV68 nor the minimally persistent M3LacZ primes the T cell response to the extent that a WT gammaHV68 challenge fails to establish latency in the microMT mice. Memory CD4(+) and CD8(+) T cells thus act together to limit gammaHV68 infection but are unable to provide absolute protection against a high-dose, homologous challenge. |
