| First Author | Hondowicz BD | Year | 2018 |
| Journal | Eur J Immunol | Volume | 48 |
| Issue | 1 | Pages | 80-86 |
| PubMed ID | 28948612 | Mgi Jnum | J:336386 |
| Mgi Id | MGI:6110672 | Doi | 10.1002/eji.201746928 |
| Citation | Hondowicz BD, et al. (2018) IL-2 is required for the generation of viral-specific CD4(+) Th1 tissue-resident memory cells and B cells are essential for maintenance in the lung. Eur J Immunol 48(1):80-86 |
| abstractText | CD4(+) tissue resident cells are an important first line of defense against viral infections in the lungs and are critical for promoting the localization of lung resident CD8(+) T cells. However, relatively little is known about the signaling programs required for the development of viral-specific CD4(+) tissue resident cells in the lungs. Recently, it was shown that signaling through the high affinity IL-2 receptor is required for the differentiation of lung-resident Th2 memory (Trm) cells in a murine model of airway inflammation. We therefore tested if IL-2 signaling is also required for the development of viral antigen-specific CD4(+) Th1 cells in the lung after i.n. infection with lymphocytic choriomeningitis virus. These studies demonstrate that Th1 CD4(+) T cells also require IL-2 for lung Trm development. Additionally, they show that B cells potently inhibit early Th1 cell lung residency, but are required for the maintenance of a long-lived population of CD4(+) Th1 Trm. |
