| First Author | Pasare C | Year | 2005 |
| Journal | Nature | Volume | 438 |
| Issue | 7066 | Pages | 364-8 |
| PubMed ID | 16292312 | Mgi Jnum | J:102766 |
| Mgi Id | MGI:3608048 | Doi | 10.1038/nature04267 |
| Citation | Pasare C, et al. (2005) Control of B-cell responses by Toll-like receptors. Nature 438(7066):364-8 |
| abstractText | Toll-like receptors (TLRs) detect microbial infection and have an essential role in the induction of immune responses. TLRs can directly induce innate host defence responses, but the mechanisms of TLR-mediated control of adaptive immunity are not fully understood. Although TLR-induced dendritic cell maturation is required for activation of T-helper (T(H)) cells, the role of TLRs in B-cell activation and antibody production in vivo is not yet known. Here we show that activation and differentiation of T(H) cells is not sufficient for the induction of T-dependent B-cell responses. We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells. |
