| First Author | Akkaya M | Year | 2018 |
| Journal | Nat Immunol | Volume | 19 |
| Issue | 3 | Pages | 255-266 |
| PubMed ID | 29476183 | Mgi Jnum | J:282376 |
| Mgi Id | MGI:6380743 | Doi | 10.1038/s41590-018-0052-z |
| Citation | Akkaya M, et al. (2018) Toll-like receptor 9 antagonizes antibody affinity maturation. Nat Immunol 19(3):255-266 |
| abstractText | Key events in T cell-dependent antibody responses, including affinity maturation, are dependent on the B cell's presentation of antigen to helper T cells at critical checkpoints in germinal-center formation in secondary lymphoid organs. Here we found that signaling via Toll-like receptor 9 (TLR9) blocked the ability of antigen-specific B cells to capture, process and present antigen and to activate antigen-specific helper T cells in vitro. In a mouse model in vivo and in a human clinical trial, the TLR9 agonist CpG enhanced the magnitude of the antibody response to a protein vaccine but failed to promote affinity maturation. Thus, TLR9 signaling might enhance antibody titers at the expense of the ability of B cells to engage in germinal-center events that are highly dependent on B cells' capture and presentation of antigen. |
