| First Author | Kato M | Year | 2015 |
| Journal | J Virol | Volume | 89 |
| Issue | 2 | Pages | 1468-73 |
| PubMed ID | 25378499 | Mgi Jnum | J:261222 |
| Mgi Id | MGI:6148125 | Doi | 10.1128/JVI.02293-14 |
| Citation | Kato M, et al. (2015) Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection. J Virol 89(2):1468-73 |
| abstractText | Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4+ T cells. |
