| First Author | Sapoznikov A | Year | 2007 |
| Journal | J Exp Med | Volume | 204 |
| Issue | 8 | Pages | 1923-33 |
| PubMed ID | 17646404 | Mgi Jnum | J:125954 |
| Mgi Id | MGI:3760233 | Doi | 10.1084/jem.20062373 |
| Citation | Sapoznikov A, et al. (2007) Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33 |
| abstractText | Plasmacytoid dendritic cells (PDCs) play a pivotal role as cytokine-secreting accessory cells in the antimicrobial immune defense. In contrast, the capacity of PDCs to act as antigen-presenting cells in naive T cell priming remains unclear. By studying T cell responses in mice that lack conventional DCs (cDCs), and by the use of a PDC-specific antigen-targeting strategy, we show that PDCs can initiate productive naive CD4(+) T cell responses in lymph nodes, but not in the spleen. PDC-triggered CD4(+) T cell responses differed from cDC-driven responses in that they were not associated with concomitant CD8(+) T cell priming. Our results establish PDCs as a bona fide DC subset that initiates unique CD4(+) Th cell-dominated primary immune responses. |
