| First Author | Khan AR | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 5997 | PubMed ID | 25609381 |
| Mgi Jnum | J:219708 | Mgi Id | MGI:5629605 |
| Doi | 10.1038/ncomms6997 | Citation | Khan AR, et al. (2015) PD-L1hi B cells are critical regulators of humoral immunity. Nat Commun 6:5997 |
| abstractText | Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4(+)CXCR5(+)PD-1(+) follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to alphaCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases. |
