| First Author | Sonoda E | Year | 1997 |
| Journal | Immunity | Volume | 6 |
| Issue | 3 | Pages | 225-33 |
| PubMed ID | 9075923 | Mgi Jnum | J:79556 |
| Mgi Id | MGI:2388470 | Doi | 10.1016/s1074-7613(00)80325-8 |
| Citation | Sonoda E, et al. (1997) B cell development under the condition of allelic inclusion. Immunity 6(3):225-33 |
| abstractText | Mice whose IgH alleles are engineered to encode two distinct antibody heavy (H) chains generate a normal-sized B cell compartment in which most cells stably express the two heavy chains. This demonstrates that 'toxicity' of bi-allelic H chain expression and cell-autonomous mechanisms of silencing in-frame IgH gene rearrangements do not significantly contribute to allelic exclusion at the IgH locus. Notwithstanding, the stability of the various engineered IgH loci during B cell development in the bone marrow differed substantially from each other. |
