| First Author | Pape KA | Year | 2003 |
| Journal | J Exp Med | Volume | 197 |
| Issue | 12 | Pages | 1677-87 |
| PubMed ID | 12796466 | Mgi Jnum | J:116662 |
| Mgi Id | MGI:3694789 | Doi | 10.1084/jem.20012065 |
| Citation | Pape KA, et al. (2003) Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med 197(12):1677-87 |
| abstractText | The life history of isotype-switched B cells is unclear, in part, because of an inability to detect rare antigen-specific B cells at early times during the immune response. To address this issue, a small population of B cells carrying targeted antibody transgenes capable of class switching was monitored in immunized mice. After contacting helper T cells, the first switched B cells appeared in follicles rather than in the red pulp, as was expected. Later, some of the switched B cells transiently occupied the red pulp and marginal zone, whereas others persisted in germinal centers (GCs). Antigen-experienced IgM B cells were rarely found in GCs, indicating that these cells switched rapidly after entering GCs or did not persist in this environment. |
