| First Author | Vu Van D | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 10875 | PubMed ID | 26915335 |
| Mgi Jnum | J:234832 | Mgi Id | MGI:5790927 |
| Doi | 10.1038/ncomms10875 | Citation | Vu Van D, et al. (2016) Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells. Nat Commun 7:10875 |
| abstractText | Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5(+) Bcl-6(+) T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. |
