| First Author | Kitamura D | Year | 1992 |
| Journal | Cell | Volume | 69 |
| Issue | 5 | Pages | 823-31 |
| PubMed ID | 1591779 | Mgi Jnum | J:64284 |
| Mgi Id | MGI:1889053 | Doi | 10.1016/0092-8674(92)90293-l |
| Citation | Kitamura D, et al. (1992) A critical role of lambda 5 protein in B cell development. Cell 69(5):823-31 |
| abstractText | The lambda 5 gene is a homolog of immunoglobulin J lambda-C lambda genes, expressed specifically in immature B-lineage cells. Lambda 5-encoded molecules form membrane complexes with mu or D mu proteins in association with an additional protein specifically expressed in immature B cells that is encoded by the Vpre-B gene. We have generated mice in which the lambda 5 gene is inactivated by targeted gene disruption in embryonic stem cells. In these mice, B cell development in the bone marrow is blocked at the pre-B cell stage. However, the blockade is leaky, allowing B cells to populate the peripheral immune system at a low rate. These cells are allelically excluded and able to respond to antigen. |
