| First Author | D'Souza WN | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 11 | Pages | 5727-35 |
| PubMed ID | 14634080 | Mgi Jnum | J:117985 |
| Mgi Id | MGI:3698325 | Doi | 10.4049/jimmunol.171.11.5727 |
| Citation | D'Souza WN, et al. (2003) IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol 171(11):5727-35 |
| abstractText | Based primarily on in vitro data, IL-2 is believed to be the key cytokine for initiation of the cell cycle of activated T cells. However, the role of IL-2 remains unresolved for T cell responses in vivo. We examined whether the absence of IL-2-mediated signaling in CD8 T cells affected initiation of proliferation. Our results conclusively demonstrated that initial division of Ag-specific CD8 T cells following priming was IL-2 independent, regardless of the context in which Ag was presented. In contrast, the latter stage of the proliferative phase was IL-2-dependent, particularly in nonlymphoid tissues. Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence. |
