| First Author | Hu DY | Year | 2017 |
| Journal | Cell Death Differ | Volume | 24 |
| Issue | 6 | Pages | 1007-1016 |
| PubMed ID | 28362433 | Mgi Jnum | J:268799 |
| Mgi Id | MGI:6269738 | Doi | 10.1038/cdd.2017.38 |
| Citation | Hu DY, et al. (2017) IL-2 prevents deletion of developing T-regulatory cells in the thymus. Cell Death Differ 24(6):1007-1016 |
| abstractText | In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8- CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second. |
