| First Author | Dai Z | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 6 | Pages | 3031-6 |
| PubMed ID | 10975812 | Mgi Jnum | J:64553 |
| Mgi Id | MGI:1889475 | Doi | 10.4049/jimmunol.165.6.3031 |
| Citation | Dai Z, et al. (2000) The dual role of IL-2 in the generation and maintenance of CD8+ memory T cells. J Immunol 165(6):3031-6 |
| abstractText | The mechanisms responsible for the generation and maintenance of T cell memory are unclear. In this study, we tested the role of IL-2 in allospecific CD8+ T cell memory by analyzing the long-term survival, phenotype, and functional characteristics of IL-2-replete (IL-2+/+) and IL-2-deficient (IL-2-/-) CD8+ TCR-transgenic lymphocytes in an adoptive transfer model. We found that IL-2 is not essential for the in vivo generation, maintenance, or recall response of CD8+ memory T cells. However, IL-2 increased the size of the CD8+ memory pool if present at the time of initial T cell activation but reduced the size of the pool if present during memory maintenance by inhibiting the proliferation of CD8+ memory T cells. Thus, IL-2-based vaccine strategies or immunosuppressive regimens that target IL-2 should take into account the divergent roles of IL-2 in CD8+ T cell immunity. |
