| First Author | Sadlack B | Year | 1994 |
| Journal | Eur J Immunol | Volume | 24 |
| Issue | 1 | Pages | 281-4 |
| PubMed ID | 7517363 | Mgi Jnum | J:16662 |
| Mgi Id | MGI:64730 | Doi | 10.1002/eji.1830240144 |
| Citation | Sadlack B, et al. (1994) Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur J Immunol 24(1):281-4 |
| abstractText | Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2 and IL-4-deficient homozygous mice. |
