| First Author | D'Cruz LM | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 11 | Pages | 1152-9 |
| PubMed ID | 16227983 | Mgi Jnum | J:112603 |
| Mgi Id | MGI:3662824 | Doi | 10.1038/ni1264 |
| Citation | D'Cruz LM, et al. (2005) Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6(11):1152-9 |
| abstractText | Interleukin 2 signaling is believed to be critically involved in several aspects of CD25(+) CD4(+) regulatory T cell biology, such as intrathymic development, peripheral survival and suppressive function. Here we have analyzed the effects of interleukin 2 or CD25 deficiency on agonist-driven thymic development and the peripheral homeostasis of an antigen-specific population of regulatory T cells positive for forkhead family transcription factor Foxp3 and have correlated our observations with polyclonal suppressor populations. We found that the differentiation, acquisition of functional capacity and formation of a sizeable pool of suppressor T cells in the thymus was independent of interleukin 2 signaling, but that interleukin 2 was essential for the survival of mature Foxp3(+) regulatory T cells. |
