| First Author | Konkel JE | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 4 | Pages | 312-9 |
| PubMed ID | 21297643 | Mgi Jnum | J:170346 |
| Mgi Id | MGI:4946345 | Doi | 10.1038/ni.1997 |
| Citation | Konkel JE, et al. (2011) Control of the development of CD8alphaalpha(+) intestinal intraepithelial lymphocytes by TGF-beta. Nat Immunol 12(4):312-9 |
| abstractText | The molecular mechanisms that direct the development of TCRalphabeta(+)CD8alphaalpha(+) intestinal intraepithelial lymphocytes (IELs) are not thoroughly understood. Here we show that transforming growth factor-beta (TGF-beta) controls the development of TCRalphabeta(+)CD8alphaalpha(+) IELs. Mice with either a null mutation in the gene encoding TGF-beta1 or T cell-specific deletion of TGF-beta receptor I lacked TCRalphabeta(+)CD8alphaalpha(+) IELs, whereas mice with transgenic overexpression of TGF-beta1 had a larger population of TCRalphabeta(+)CD8alphaalpha(+) IELs. We observed defective development of the TCRalphabeta(+)CD8alphaalpha(+) IEL thymic precursors (CD4(-)CD8(-)TCRalphabeta(+)CD5(+)) in the absence of TGF-beta. In addition, we found that TGF-beta signaling induced CD8alpha expression in TCRalphabeta(+)CD8alphaalpha(+) IEL thymic precursors and induced and maintained CD8alpha expression in peripheral populations of T cells. Our data demonstrate a previously unrecognized role for TGF-beta in the development of TCRalphabeta(+)CD8alphaalpha(+) IELs and the expression of CD8alpha in T cells. |
