| First Author | Kündig TM | Year | 1993 |
| Journal | Science | Volume | 262 |
| Issue | 5136 | Pages | 1059-61 |
| PubMed ID | 8235625 | Mgi Jnum | J:15573 |
| Mgi Id | MGI:63690 | Doi | 10.1126/science.8235625 |
| Citation | Kundig TM, et al. (1993) Immune responses in interleukin-2-deficient mice. Science 262(5136):1059-61 |
| abstractText | The role of costimulatory signals in T cell induction was evaluated in mice lacking the interleukin-2 (IL-2) gene. In vitro secondary antiviral T cell responses were absent unless IL-2 was added, confirming the crucial role of IL-2 in vitro. In vivo, primary and secondary cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were within normal ranges. B cell reactivity to vesicular stomatitis virus was not impaired. T helper cell responses were delayed but biologically functional. Natural killer cell activity was markedly reduced but inducible. These normal in vivo immune responses in IL-2-deficient mice question the importance of IL-2 as defined by in vitro studies. |
