| First Author | Ballesteros-Tato A | Year | 2012 |
| Journal | Immunity | Volume | 36 |
| Issue | 5 | Pages | 847-56 |
| PubMed ID | 22464171 | Mgi Jnum | J:187331 |
| Mgi Id | MGI:5436203 | Doi | 10.1016/j.immuni.2012.02.012 |
| Citation | Ballesteros-Tato A, et al. (2012) Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36(5):847-56 |
| abstractText | T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh cell differentiation in vivo are incompletely understood. Here we show that interleukin-2 (IL-2) administration impaired influenza-specific GCs, long-lived IgG responses, and Tfh cells. IL-2 did not directly inhibit GC formation, but instead suppressed the differentiation of Tfh cells, thereby hindering the maintenance of influenza-specific GC B cells. Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development. |
