| First Author | Kronin V | Year | 1998 |
| Journal | Int Immunol | Volume | 10 |
| Issue | 2 | Pages | 237-40 |
| PubMed ID | 9533452 | Mgi Jnum | J:110430 |
| Mgi Id | MGI:3640224 | Doi | 10.1093/intimm/10.2.237 |
| Citation | Kronin V, et al. (1998) Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?. Int Immunol 10(2):237-40 |
| abstractText | The IL-2 receptor (IL-2R) alpha chain (CD25), but not the IL-2R beta chain, is induced on dendritic cells (DC) by brief periods of culture. To test if this IL-2R alpha is important for DC function, DC were isolated from the spleens of mutant mice with the IL-2R alpha gene disrupted and compared with normal DC for ability to stimulate proliferation of allogeneic CD4 and CD8 T cells in culture. The IL-2R alpha null DC and the normal DC produced nearly identical proliferative responses from CD4 and from CD8 T cells. When the CD8 alpha+ and CD8 alpha- subsets of the IL-2R alpha null DC were separated, they also produced proliferative responses similar to that of their normal DC counterparts. Overall there was no evidence that the inducible IL-2R alpha on DC was required for DC development, for stimulation of T cells or for regulation of T cell responses. |
