| First Author | Hayashi RJ | Year | 2006 |
| Journal | Int Immunol | Volume | 18 |
| Issue | 5 | Pages | 645-51 |
| PubMed ID | 16574670 | Mgi Jnum | J:108552 |
| Mgi Id | MGI:3624230 | Doi | 10.1093/intimm/dxh397 |
| Citation | Hayashi RJ, et al. (2006) Requirement of high-affinity IL-2-IL-2R interaction for T cell anergy induction. Int Immunol 18(5):645-51 |
| abstractText | Incomplete T cell antigen receptor-mediated signaling induces an unresponsive state known as anergy. Previously, we had shown that anergy can be induced in antigen-primed but not naive T cells. In this report, we found that in vitro primed T cells from IL-2Ralpha-deficient mice were resistant to anergy induction in contrast to comparably treated wild-type T cells. This resistance persisted even after proliferation of IL-2Ralpha chain-deficient CD4 T cells with high-dose IL-2-IL-2Rbetagamma chains interaction. Thus, antigen activation, and/or progression through cell cycle are not sufficient to induce anergy susceptibility in T cells. The high-affinity IL-2-IL-2R interaction appears to play a critical role in this process. |
