| First Author | Kim D | Year | 2022 |
| Journal | J Exp Med | Volume | 219 |
| Issue | 5 | PubMed ID | 35315876 |
| Mgi Jnum | J:331109 | Mgi Id | MGI:7384210 |
| Doi | 10.1084/jem.20200795 | Citation | Kim D, et al. (2022) Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25. J Exp Med 219(5):e20200795 |
| abstractText | Lymph node fibroblastic reticular cells (LN-FRCs) provide functional structure to LNs and play important roles in interactions between T cells and antigen-presenting cells. However, the direct impact of LN-FRCs on naive CD4+ T cell differentiation has not been explored. Here, we show that T cell zone FRCs of LNs (LN-TRCs) express CD25, the alpha chain of the IL-2 receptor heterotrimer. Moreover, LN-TRCs trans-present IL-2 to naive CD4+ T cells through CD25, thereby facilitating early IL-2-mediated signaling. CD25-deficient LN-TRCs exhibit attenuated STAT5 phosphorylation in naive CD4+ T cells during T cell differentiation, promoting T helper 17 (Th17) cell differentiation and Th17 response-related gene expression. In experimental autoimmune disease models, disease severity was elevated in mice lacking CD25 in LN-TRCs. Therefore, our results suggest that CD25 expression on LN-TRCs regulates CD4+ T cell differentiation by modulating early IL-2 signaling of neighboring, naive CD4+ T cells, influencing the overall properties of immune responses. |
