| First Author | Martin CE | Year | 2017 |
| Journal | Immunity | Volume | 47 |
| Issue | 1 | Pages | 171-182.e4 |
| PubMed ID | 28723549 | Mgi Jnum | J:260577 |
| Mgi Id | MGI:6142673 | Doi | 10.1016/j.immuni.2017.07.005 |
| Citation | Martin CE, et al. (2017) Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells. Immunity 47(1):171-182.e4 |
| abstractText | Interleukin-7 (IL-7) availability determines the size and proliferative state of the resting T cell pool. However, the mechanisms that regulate steady-state IL-7 amounts are unclear. Using experimental lymphopenic mouse models and IL-7-induced homeostatic proliferation to measure IL-7 availability in vivo, we found that radioresistant cells were the source of IL-7 for both CD4(+) and CD8(+) T cells. Hematopoietic lineage cells, although irrelevant as a source of IL-7, were primarily responsible for limiting IL-7 availability via their expression of IL-7R. Unexpectedly, innate lymphoid cells were found to have a potent influence on IL-7 amounts in the primary and secondary lymphoid tissues. These results demonstrate that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells. |
