| First Author | Gong D | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 1 | Pages | 242-52 |
| PubMed ID | 17182561 | Mgi Jnum | J:141935 |
| Mgi Id | MGI:3820041 | Doi | 10.4049/jimmunol.178.1.242 |
| Citation | Gong D, et al. (2007) Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J Immunol 178(1):242-52 |
| abstractText | After Ag activation of naive T cells in vitro, extensive growth and differentiation into effector cells depend upon IL-2. DNA microarray analysis was used to identify IL-2-dependent molecules regulating this process. In this study, we show that the transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp-1) is expressed by a cytokine-dependent pathway in activated T lymphocytes. IL-2 production by activated CD4(+) and CD8(+) T cells inversely correlated with Blimp-1 levels as higher IL-2 production was associated with lower Blimp-1 expression. Furthermore, ectopic expression of Blimp-1 by activated T cells inhibited IL-2 production but enhanced granzyme B and CD25 expression. Collectively, these findings indicate that there is a negative feedback regulatory loop in activated T cells such that IL-2 inhibits its own production through induction of Blimp-1 while promoting an effector cell phenotype. |
