Primary Identifier | MGI:1933774 | Allele Type | Targeted |
Attribute String | Inserted expressed sequence, Null/knockout | Gene | Myf5 |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Deletion of all Myf5 coding sequences in exon 1 and replacement with the complete Myog coding region followed by a stop codon. A lox-P flanked neomycin cassette was also inserted downstream of the Myog coding region, but was removed via Cre-mediated recombination in ES cells prior to the generation of chimeric founder mice. This allele expresses a functional Myogenin protein under the control of the Myf5 promoter. |