| First Author | Svensson L | Year | 2001 |
| Journal | J Reprod Immunol | Volume | 51 |
| Issue | 1 | Pages | 3-7 |
| PubMed ID | 11438376 | Mgi Jnum | J:70597 |
| Mgi Id | MGI:2137824 | Doi | 10.1016/s0165-0378(01)00065-1 |
| Citation | Svensson L, et al. (2001) The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51(1):3-7 |
| abstractText | The physiological protection from fetal rejection is believed to be dependent on a Th2 type of inflammatory response at the maternal-fetal interface and the cytokines IL-4 and IL-10 have been suggested to play a critical role. We here present data from breeding experiments with IL-10 and IL-4 double-deficient mice indicating that neither maternal nor feto-placental deficiency of these cytokines are crucial for fetal or neonatal survival. The present study does not analyse possible developmental effects of maternal or fetal IL-10 and IL-4 double-deficiency in detail, but shows that an apparently normal breeding can be achieved in different crossings, providing that the mice are kept under very clean conditions. |
