| First Author | Keogh B | Year | 2002 |
| Journal | J Neuroimmunol | Volume | 125 |
| Issue | 1-2 | Pages | 15-22 |
| PubMed ID | 11960636 | Mgi Jnum | J:102960 |
| Mgi Id | MGI:3608273 | Doi | 10.1016/s0165-5728(02)00014-0 |
| Citation | Keogh B, et al. (2002) Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: a role for Th1 cells in the protective immunity. J Neuroimmunol 125(1-2):15-22 |
| abstractText | Experimental infection of mice with avirulent Semliki Forest virus (SFV) has been used as a model of demyelinating disease in humans. A number of studies have shown that T cells may be important for mediating demyelination, but the role of T cells is still, unclear. Here, we show that neuronal necrosis, but not demyelination, was more severe in interleukin (IL)-12-defective mice compared with wild-type mice and this correlated with higher virus titers in the brain. In contrast, the severity of demyelination and neuronal depletion was reduced in IL-4-defective mice and this correlated with reduced brain virus titers and enhanced SFV-specific IFN-gamma production. The findings indicate that type 1 T cells play a role in the control of SFV replication but not directly in SFV-induced pathology in the CNS. |
