| First Author | Thieu VT | Year | 2007 |
| Journal | J Leukoc Biol | Volume | 82 |
| Issue | 2 | Pages | 370-9 |
| PubMed ID | 17513694 | Mgi Jnum | J:123512 |
| Mgi Id | MGI:3718756 | Doi | 10.1189/jlb.1106707 |
| Citation | Thieu VT, et al. (2007) IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol 82(2):370-9 |
| abstractText | IL-4 is a critical cytokine in the regulation of immune responses. In B lymphocytes, IL-4 signaling promotes the Stat6-dependent cell surface expression of several proteins including MHC Class II and CD86. However, the requirement for other transcription factors in IL-4-induced B cell gene expression has not been studied extensively. Here, we show that IL-4 induces NF-kappaB p100 processing to NF-kappaB p52 in B cells but not in T cells or macrophages. IL-4 induced NF-kappaB p52 production requires PI-3K activity and correlates with IkappaB kinase phosphorylation and TNF receptor-associated factor 3 degradation. Blocking NF-kappaB activity eliminates IL-4-stimulated gene expression in B cells by reducing IL-4-induced DNA binding but not phosphorylation or nuclear localization of Stat6. These results describe a novel role for NF-kappaB in IL-4-induced signaling and gene expression. |
