| First Author | Spencer L | Year | 2001 |
| Journal | Infect Immun | Volume | 69 |
| Issue | 12 | Pages | 7743-52 |
| PubMed ID | 11705956 | Mgi Jnum | J:73137 |
| Mgi Id | MGI:2154614 | Doi | 10.1128/IAI.69.12.7743-7752.2001 |
| Citation | Spencer L, et al. (2001) Interleukin-4 receptor-stat6 signaling in murine infections with a tissue-dwelling nematode parasite. Infect Immun 69(12):7743-52 |
| abstractText | Interleukin-4 (IL-4) has been shown to be crucial in parasite expulsion in several gastrointestinal nematode infection models. Data from both epidemiological studies with humans and experimental infections in animals imply a critical role for the type II helper response, dominated by IL-4, in host protection. Here we utilized inbred mice on two distinct backgrounds to document the involvement of IL-4 in the clearance of a primary infection of Brugia from the murine host. Our data from infections of IL-4 receptor(-/-) and Stat6(-/-) mice further indicate that IL-4 exerts its effects by activating the Stat6 molecule in host target cells, a finding which links clearance requirements of a gastrointestinal tract-dwelling nematode with those of a tissue-dwelling nematode. Additionally, we show that the requirements for IL-4 receptor binding and Stat6 activation extend to accelerated clearance of a secondary infection as well. The data shown here, including analysis of cell populations at the site of infection and infection of immunoglobulin E (IgE)(-/-) mice, lead us to suggest that deficiencies in eosinophil recruitment and isotype switching to IgE production may be at least partially responsible for slower parasite clearance in the absence of IL-4. |
