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Allele : Il6<tm1Kopf> interleukin 6; targeted mutation 1, Manfred Kopf

Primary Identifier  MGI:1857197 Allele Type  Targeted
Attribute String  Null/knockout Gene  Il6
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice.
  • mutations:
  • Insertion
  • synonyms:
  • Il6<tm1Koe>,
  • Il6-,
  • IL-6 KO,
  • Il6<tm1Kopf>,
  • IL-6 KO,
  • Il6-,
  • Il6<tm1Koe>,
  • Il6<tm1Kopf>,
  • IL-6-,
  • IL-6-
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

11 Carried By

Trail: Allele

0 Driven By

715 Publication categories

Trail: Allele