| First Author | Fujimaki H | Year | 2006 |
| Journal | Immunopharmacol Immunotoxicol | Volume | 28 |
| Issue | 4 | Pages | 703-14 |
| PubMed ID | 17190745 | Mgi Jnum | J:136469 |
| Mgi Id | MGI:3796362 | Doi | 10.1080/08923970601067433 |
| Citation | Fujimaki H, et al. (2006) Distinct requirements for interleukin-6 in airway inflammation induced by diesel exhaust in mice. Immunopharmacol Immunotoxicol 28(4):703-14 |
| abstractText | To clarify the possible role of interleukin-6 in aggravation of inflammatory responses in diesel exhaust-exposed mice, we compared the infiltration of inflammatory cells and the production of chemokines between interleukin-6-deficient and wild-type mice following 0, 1.0, or 3.0 mg diesel particles/m3 diesel exhaust inhalation for 4 weeks. Exposure to diesel exhaust significantly increased the number of inflammatory cells and the amount of CCL17 and CXCL3 in bronchoalveolar lavage fluids from wild-type mice, but not in interleukin-6-deficient mice. These findings suggest that interleukin-6 plays a critical role in airway inflammatory responses induced by diesel exhaust inhalation. |
