| First Author | Keller C | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 321 |
| Issue | 1 | Pages | 179-82 |
| PubMed ID | 15358232 | Mgi Jnum | J:91303 |
| Mgi Id | MGI:3046411 | Doi | 10.1016/j.bbrc.2004.06.129 |
| Citation | Keller C, et al. (2004) Exercise normalises overexpression of TNF-alpha in knockout mice. Biochem Biophys Res Commun 321(1):179-82 |
| abstractText | TNF-alpha is linked with insulin resistance, as greater amounts of TNF are detected in muscle and adipose tissue in glycemically challenged people and TNF-alpha inhibits insulin receptor signalling. However, what modulates this overexpression of TNF-alpha is currently unknown. We examined the effect of 1 h exercise on overexpression of the TNF-alpha gene in TNF receptor 1 and 2 knockout mice. IL-6 knockout mice were included to elucidate the importance of IL-6 in regulating TNF-alpha in response to exercise. TNF-alpha gene expression was over-expressed in muscle in both TNFR knockout models. TNF-alpha overexpression returned to normal levels after exercise in the TNF-alpha receptor knockout models. In IL-6 knockout mice, a modest decrease in TNF-alpha was also observed. These data suggest that TNF-alpha-induced insulin resistance can be regulated by a single exercise bout by normalising TNF-alpha expression. This exercise effect can be mediated via IL-6, but also an IL-6 independent mechanism seems to exist. |
